February 2, 2021

Bill Prady: Origins of Sheldon. Neurodiversity & Sensory Overload

Bill Prady, co-creator of "The Big Bang Theory," discusses how he came up with the idea to make a show about socially challenged scientists. What many may not know is that Prady himself is on the autism spectrum. Mayim explains "neuro-a typical' and sensory overload, and Bill opens up about his quirks and his challenges and shares intimately about his journey from awkward child and teen to well-adjusted, if eccentric, adult.

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Mayim Bialik


Jonathan Cohen


Bill Prady

Co-creator of "The Big Bang Theory"

@ billprady



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Guest References

Family-Based Association Studies: OCD

OCD is commonly diagnosed with major depressive disorder. Studies have shown that there is a genetic component for thecause and susceptibility of OCD, but the mode of inheriting this genetic factor is unknown. There are two genes that contribute to OCD susceptibility, but gender may play a role in this genetic predisposition.

Tip and Tricks to Manage OCD
Read these 25 tips for succeeding in your OCD treatment...
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Genome-Wide Association Study of OCD
Genetic studies have shown that biological and environmental factors are important to learning more about the causes of OCD.OCD is heritable, specifically in certain chromosomes. This is only a small proportion of the total genetic variance explained. While looking at the genetics, this study also looked at theeffects of gene expression versus methylation, which is when genes are not expressed.
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Gene Regulation
Gene regulation is the process of turning genes on and off. During early development, cells begin to take on specific functions. Gene regulation ensures that the appropriate genes are expressed at the proper times. Gene regulation can also help an organism respond to its environment. Gene regulation is accomplished by a variety of mechanisms including chemically modifying genes and using regulatory proteins to turn genes on or off.
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