Sarah Silverman (The Sarah Silverman Podcast, The Sarah Silverman Program, I Love You, America, Wreck It Ralph, Santa Inc., author of The Bedwetter) discusses the origins of her "shock value" comedy style, her reaction to being called "one of the guys" in comedy, and the importance of growing and changing with the times, especially as a comedian. She opens up about the trauma passed down within her family, the moment that led her to receive a depression diagnosis, and her experience with being overprescribed medication. Sarah shares her tools for managing panic attacks, the benefits of coupling medication with talk therapy, and the importance of laughter in staying youthful. She reveals why she doesn’t let club hecklers or internet trolls get to her, and considers the cognitive distortion of memory caused by one’s own perspective. Mayim examines the importance of truly expressing oneself within a relationship, the internal and external manifestations of anxiety, and it’s hereditary and environmental causes.